- Hemophilia is one of a group of inherited bleeding disorders that
cause abnormal or exaggerated bleeding and poor blood clotting.
- Hemophilia A and
B are inherited in an X-linked recessive genetic pattern, so males are
commonly affected while females are usually carriers of the disease.
- Hemophilia A is caused by a deficiency of clotting
Factor VIII, while hemophilia B (also
called Christmas disease) results from a deficiency of Factor IX.
- Hemophilia varies in its severity among affected
individuals.
- Symptoms include excessive bleeding from any site in
the body; long-term damage to joints from repeated bleeding episodes is
characteristic.
- Treatment involves coagulation factor replacement
therapy.
- The formation of inhibitors to the treatment factor
concentrates is a significant complication of treatment.
- Gene therapy treatments are a source of active research
and hold promise for the future.
source : http://www.medicinenet.com/hemophilia/article.htm
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